docTLDR

A new study reveals that specific tumor cell gene expression signatures in diffuse large B-cell lymphoma (DLBCL) can predict patient response to CAR-T cell therapy. Researchers identified molecular patterns linked to better outcomes, suggesting that pre-treatment tumor profiling could guide personalized CAR-T strategies and improve remission rates for DLBCL patients.

International laser charities are providing advanced dermatological laser treatments in low- and middle-income countries, addressing severe skin conditions like scars, burns, and birthmarks. These initiatives not only restore physical appearance but also improve psychological well-being and social integration for patients who otherwise lack access to such care.

Portugal’s prison system is grappling with a critical shortage of psychiatrists, leaving many inmates with mental health conditions underserved. Despite reforms to integrate prison health into the national system, staff shortages and high patient loads persist, exacerbating mental health crises and delaying care. The government’s ongoing efforts aim to close this gap, but challenges remain acute.

A new study highlights that sexual dysfunction and distress remain prevalent among cervical cancer survivors, even years after treatment. Over 60% of women reported persistent sexual issues, including pain, reduced desire, and emotional distress. The findings underscore the need for routine sexual health assessments and tailored interventions in survivorship care.

Emerging technologies and family-centered care models are transforming neurodiversity management by improving early detection, personalized interventions, and support for neurodivergent individuals. These innovations aim to close care gaps, enhance outcomes, and foster inclusion, with implications for clinicians, families, and healthcare systems worldwide.

Large randomized trials show remote ischemic preconditioning (RIPC) does not significantly lower rates of death, myocardial infarction, stroke, or acute renal failure in patients undergoing elective cardiac surgery compared to sham interventions. While RIPC is safe, it offers no added clinical benefit for major postoperative outcomes, challenging its routine use for cardioprotection in this setting.

Recent real-world studies indicate that IL-23 inhibitors, including tildrakizumab, guselkumab, and risankizumab, are safe and effective for moderate-to-severe plaque psoriasis, even in patients with a history of cancer. Data show low rates of cancer progression or recurrence, supporting their use on a case-by-case basis with oncology consultation. Larger studies are still needed to confirm long-term safety.

For patients with suspected axial spondyloarthritis (axSpA), MRI is increasingly favored over X-rays as the initial imaging modality. MRI detects early inflammatory changes, such as bone marrow edema, that X-rays often miss, enabling earlier diagnosis and intervention. Updated guidelines emphasize MRI’s superior sensitivity for early disease, while X-rays remain useful for assessing structural damage in established cases. Close collaboration between rheumatologists and radiologists is crucial...